Abstract #0578
Laminar-resolution BOLD and CBV fMRI responding to layer-specific neural modulations in the olfactory bulb
Alexander Poplawsky 1 , Mitsuhiro Fukuda 1 , Xiaopeng Zong 2 , and Seong-Gi Kim 1,3
1
Radiology, University of Pittsburgh,
Pittsburgh, PA, United States,
2
Biomedical
Research Imaging Center, University of North Carolina,
Chapel Hill, NC, United States,
3
Biological
Sciences, Center for Neuroscience Imaging Research,
Institute for Basic Science (IBS), SKKU, Suwon, Korea
We used high-resolution fMRI in the olfactory bulb model
to examine whether hemodynamic responses are regulated
at the laminar level. Odor and micro-stimulation of the
lateral olfactory tract (LOT) were used to
preferentially evoke activity in different bulb layers.
We found different, neural-specific laminar activation
patterns for each individual stimulation using CBV fMRI,
but not BOLD. Specifically, for CBV, a ring-like
activation was reproducibly observed only in middle
layers (~200 m thick) following LOT stimulation that
corresponds with the location of evoked neural activity.
Our data provide definitive evidence that the
hemodynamic response is regulated at the laminar level.
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