Domain Gauges: A Reference System for Multivariate Profiling of Brain fMRI Activation Patterns Induced by Psychoactive Drugs in Rats

We present domain gauges as a set of multivariate metrics to easily quantify and characterize, with only a few numbers, drug-induced brain fMRI activation patterns. The gauges have been calibrated based on different classes (domains) of marketed or validated reference drugs. Capitalizing on our in-house database with an unprecedented wealth of standardized rat-brain perfusion fMRI data, we exemplarily defined and applied 3 domain gauges to demonstrate that our approach represents a valuable analytical tool to reveal drug-related neuronal circuits and concisely assess brain activation patterns, thereby facilitating compound characterization and decision making in drug discovery.

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