Abstract #0587
Acute lesion topography relationship with clinical admission symptoms and long-term functional outcomes in stroke patients
Ona Wu 1 , Lisa Cloonan 2 , Steven Mocking 1 , Mark Bouts 1 , Jonathan Rosand 2 , Karen L. Furie 2 , and Natalia S. Rost 2
1
Athinoula A Martinos Center, Massachusetts
General Hospital, Boston, MA, United States,
2
Department
of Neurology, Massachusetts General Hospital, Boston,
United States
Neuroimaging is often proposed as a potential surrogate
for clinical outcome in the evaluation of novel stroke
therapies. We analyzed 480 patients from a prospective
single center stroke data repository using voxel-based
symptom mapping (VLSM) techniques with acute DWI lesions
and follow-up modified Rankin Scale Score and NIH Stroke
Scale Score. We found acute lesions in the left
hemisphere were associated with poor outcome. VLSM
methods may provide insight into patients at risk of
poor long-term outcome and provide guidance towards
which patients will most likely benefit from aggressive
acute intervention and follow-up physical therapy.
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