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Abstract #0595

Calibrated MRI in patients with occlusive cerebrovascular disease.

J. B. De Vis 1 , E. T. Petersen 1 , N. S. Hartkamp 1 , A. Bhogal 1 , C. J.M. Klijn 2 , L. J. Kappelle 2 , and J. Hendrikse 1

1 Radiology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands, 2 Neurology, University Medical Center Utrecht, Utrecht, Utrecht, Netherlands

Calibrated MRI is an upcoming non-invasive technique to evaluate brain metabolism. So far, it has only been evaluated in healthy volunteers and has not been used in patients yet. In this study we investigate the potential of calibrated MRI to study hemodynamic impairment in patients with cerebrovascular disease. Our patients demonstrate lower BOLD reactivity but equal oxygen extraction fraction suggesting impaired vascular reactivity. In addition, we find that blood flow through collateral pathways introduces artefacts in 27% of our patients limiting the use of calibrated MRI in patients with cerebrovascular disease.

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