Probing Internal-Gradient-Distribution-Tensors (IGDT) by Non-Uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI: A New Approach to Map Orientations in Biological Tissues
Noam Shemesh 1 , Gonzalo A Alvarez 1 , and Lucio Frydman 1
Chemical Physics, Faculty of Chemistry,
Weizmann Institute of Science, Rehovot, Israel
DTI, STI and T2* are powerful methods for mapping
orientations, yet they demand either diffusion path
lengths that fully probe confining boundaries or the
rotation of specimens about B0. Han et al recently
proposed the internal-gradient-distribution-tensor (IGDT)
as a novel source of orientational contrast. Here we
develop a new, fully-refocused approach based on
Non-uniform Oscillating-Gradient Spin-Echo (NOGSE) MRI
for selectively probing these IGDT whilst keeping all
other sources of decoherence including diffusion, T2,
pulse/timing/gradient imperfections and T1 constant.
The approach is explained, and experiments in spinal
cord segments reveal the possibility of using it for
mapping WM orientations noninvasively.
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