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Abstract #0662

In-vivo diffusion q-space trajectory imaging

Carl-Fredrik Westin 1,2 , Markus Nilsson 3 , Filip Szczepankiewicz 4 , Ofer Pasternak 1 , Evren Ozarslan 1 , Daniel Topgaard 5 , and Hans Knutsson 2

1 Radiology, Brigham and Women's, Harvard Medical School, Boston, MA, United States, 2 Department of Biomedical Engineering, Linkoping University, Linkoping, Sweden, 3 Lund University Bioimaging Center, Lund University, Lund, Sweden, 4 Department of Medical Radiation Physics, Lund University, Lund, Sweden, 5 Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden

Here we study how the choice of diffusion MRI gradient modulation schemes define the geometry and dimensionality of the diffusion encoding. By defining a diffusion encoding tensor, or diffusion measurement tensor, we will in the Gaussian approximation regime bring concepts as single, double, and triple-PFG into a common framework. Careful design of the speed and shape of the q-space trajectory can produce a planar diffusion encoding that is isotropic in the selected plane. The presented work shows that it is possible to perform in vivo circular diffusion encoding imaging of the human brain with a good SNR.

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