Rotating Short-Axis EPI blades as veering diffusion gradient directions with composite reconstruction (RSA)

We propose a novel sequence, RSA, for fast and high spatial resolution advanced Diffusion-Weighted Imaging (DWI), which has been used widely to assess the integrity and directional information of white matter. Conventionally, DWI uses single-shot spin-echo EPI sequences. However, SS-EPI suffers from geometric distortion and long echo time (TE) with high spatial resolution (e.g, cubic voxel size of 1mm). Moreover, approaches using high and/or multiple b-values demand adequate SNR for accurate estimations. Because only one short-axis blade is acquired per DW direction in the RSA sequence, it reduces geometric distortion, shortens TE to increase signals, and reduces the scan time.

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