Abstract #0669
Rapid in vivo ADC Mapping of Hyperpolarized 13 C Metabolites on a Clinical 3T MR Scanner
Bertram L. Koelsch 1,2 , Galen D. Reed 1,2 , Kayvan R. Keshari 3 , Robert A. Bok 1 , Daniel B. Vigneron 1,2 , John Kurhanewicz 1,2 , and Peder E. Z. Larson 1,2
1
Department of Radiology and Biomedical
Imaging, UCSF, San Francisco, CA, United States,
2
UC
Berkeley - UCSF Graduate Program in Bioengineering, San
Francisco, CA, United States,
3
Memorial
Sloan-Kettering Cancer Center, NY, United States
Apparent diffusion coefficient (ADC) maps of water have
become useful for cancer identification and
characterization. The growing field of hyperpolarized
13
C
has also proven to be useful in identifying tumors by
measuring the real-time metabolism of hyperpolarized
13
C
pyruvate to lactate. In this study, we developed a novel
diffusion-weighted hyperpolarized
13
C
EPI sequence on a clinical 3T MR scanner to rapidly
obtain ADC maps of hyperpolarized
13
C
metabolites
in
vivo
. Clinically, ADC mapping of hyperpolarized
13
C
lactate could allow for improved classification of tumor
grade and metastatic potential by measuring both
enhanced metabolic flux and differences in lactates
microenvironment.
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