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Abstract #0669

Rapid in vivo ADC Mapping of Hyperpolarized 13 C Metabolites on a Clinical 3T MR Scanner

Bertram L. Koelsch 1,2 , Galen D. Reed 1,2 , Kayvan R. Keshari 3 , Robert A. Bok 1 , Daniel B. Vigneron 1,2 , John Kurhanewicz 1,2 , and Peder E. Z. Larson 1,2

1 Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2 UC Berkeley - UCSF Graduate Program in Bioengineering, San Francisco, CA, United States, 3 Memorial Sloan-Kettering Cancer Center, NY, United States

Apparent diffusion coefficient (ADC) maps of water have become useful for cancer identification and characterization. The growing field of hyperpolarized 13 C has also proven to be useful in identifying tumors by measuring the real-time metabolism of hyperpolarized 13 C pyruvate to lactate. In this study, we developed a novel diffusion-weighted hyperpolarized 13 C EPI sequence on a clinical 3T MR scanner to rapidly obtain ADC maps of hyperpolarized 13 C metabolites in vivo . Clinically, ADC mapping of hyperpolarized 13 C lactate could allow for improved classification of tumor grade and metastatic potential by measuring both enhanced metabolic flux and differences in lactates microenvironment.

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