Abstract #0672
Alteration of Molecular Neurochemistry: MRI-guided Delivery of Viral Vectors to the Primate Amygdala
Benjamin P Grabow 1 , Jonathan A Oler 2 , Marissa Riedel 2 , Eva M Fekete 2 , Rothem Kovner 2 , Ethan K Brodsky 1,3 , Andrew S Fox 4 , Patrick H Roseboom 2 , Marina E Emborg 1 , Ned H Kalin 2 , and Walter F Block 1,3
1
Medical Physics, University of Wisconsin,
Madison, WI, United States,
2
Psychiatry,
University of Wisconsin, Madison, WI, United States,
3
Biomedical
Engineering, University of Wisconsin, Madison, WI,
United States,
4
University
of Wisconsin, Madison, WI, United States
Progress in understanding the genetic, neurochemical,
and molecular bases of some psychiatric illnesses has
opened the possibility of using viral vectors to deliver
novel therapeutics to relevant neural circuits. As the
desired volumetric drug distributions are a factor of
ten smaller than the drug distribution volumes used in
previous trials of neuroprotective factors in
degenerative brain diseases, the requirements for
precise guidance and monitoring are significantly
higher. We demonstrate methodology for targeting the
central amygdalar nucleus, a structure critical for
coordinating the behavioral components of fear and
anxiety, in a longitudinal, non-human primate study
designed to alter anxiety temperament.
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