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Abstract #0688

Earth-field magnetic resonance imaging - investigating magnetic nanoparticle contrast in ex vivo liver

Friedrich Wetterling 1,2 , Eoin K Fox 3 , Dermot F Brougham 3 , and Oliviero Gobbo 4

1 Faculty of Engineering, Trinity College, the University of Dublin, Dublin, Leinster, Ireland, 2 Tomometrics Ltd., Dublin, Leinster, Ireland, 3 School of Chemical Sciences, Dublin City University, Dublin, Leinster, Ireland, 4 School of Pharmacy and Pharmaceutical Sciences and Institute of Neuroscience, Trinity College, the University of Dublin, Dublin, Leinster, Ireland

In the current study, an earth-field magnetic resonance imaging (EFMRI) system was used to firstly examine the effect of magnetic nanoparticles (MNP) on the longitudinal relaxation time in the polarizing field and secondly to acquire images from ex vivo livers containing MNPs. The use of MNPs as contrast agents for relaxation rate enhancement of MRI signal has been previously reported and was confirmed by our EFMRI measurements. 3D image data sets were recorded for control and MNP doped livers. We conclude that earth-field MRI at 50uT provides a promising tool to study MNP concentration changes non-invasively with sufficient spatial resolution as a model system for developing insights into bio-distribution and changes in relaxivity on localisation.

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