Abstract #0688
Earth-field magnetic resonance imaging - investigating magnetic nanoparticle contrast in ex vivo liver
Friedrich Wetterling 1,2 , Eoin K Fox 3 , Dermot F Brougham 3 , and Oliviero Gobbo 4
1
Faculty of Engineering, Trinity College, the
University of Dublin, Dublin, Leinster, Ireland,
2
Tomometrics
Ltd., Dublin, Leinster, Ireland,
3
School
of Chemical Sciences, Dublin City University, Dublin,
Leinster, Ireland,
4
School
of Pharmacy and Pharmaceutical Sciences and Institute of
Neuroscience, Trinity College, the University of Dublin,
Dublin, Leinster, Ireland
In the current study, an earth-field magnetic resonance
imaging (EFMRI) system was used to firstly examine the
effect of magnetic nanoparticles (MNP) on the
longitudinal relaxation time in the polarizing field and
secondly to acquire images from ex vivo livers
containing MNPs. The use of MNPs as contrast agents for
relaxation rate enhancement of MRI signal has been
previously reported and was confirmed by our EFMRI
measurements. 3D image data sets were recorded for
control and MNP doped livers. We conclude that
earth-field MRI at 50uT provides a promising tool to
study MNP concentration changes non-invasively with
sufficient spatial resolution as a model system for
developing insights into bio-distribution and changes in
relaxivity on localisation.
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