Abstract #0699
Effect of physical exercise on cerebral antioxidant status in older adults
In-Young Choi 1,2 , Phil Lee 1,3 , Eric D Vidoni 4 , William M Brooks 1,2 , and Jeffrey M Burns 2
1
Hoglund Brain Imaging Center, University of
Kansas Medical Center, Kansas City, KS, United States,
2
Neurology,
University of Kansas Medical Center, Kansas City, KS,
United States,
3
Molecular
& Integrative Physiology, University of Kansas Medical
Center, Kansas City, KS, United States,
4
Alzheimer's
Disease Center, University of Kansas Medical Center,
Kansas City, KS, United States
GSH is a key cerebral antioxidant that protects cells
from oxidative stress, a central process contributing to
aging and neurodegeneration, and a reduction in GSH is
noted in brain tissue undergoing oxidative stress.
Physical exercise has been suggested as a
neuroprotective strategy against loss of antioxidants.
In this study, we measured the influence of aerobic
exercise on cerebral GSH levels in older adults using
doubly-selective multiple quantum GSH CSI at 3T. The GSH
levels were significantly increased after exercise
intervention, providing insights into the effect of
exercise on the cerebral antioxidant system to promote
brain health of the aging population.
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