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Abstract #0710

Early Responses of Breast Cancer Patients to Chemotherapy with and without Anti-angiogenic Pre-treatment Monitored by Diffusion Tensor Imaging

Limiao Jiang 1 , Bo Zhang 2 , Dennis Lai-Hong Cheong 2 , Soo Chin Lee 3 , and Thian C Ng 1,2

1 Department of Diagnostic Radiology, National University of Singapore, Singapore, Singapore, 2 Clinical Imaging Research Center, A*STAR & National University of Singapore, Singapore, 3 Department of Haematology-Oncology, National University Health System, Singapore

DTI can be used to probe tissue microstructure in vivo. We used DTI to study vasculature alteration including normalization for enhancing the drug(s) delivery to breast carcinoma cells in 35 patients pre-treated with low dose Sunitinib. It showed that patients pre-treated with anti-angiogenic agent had a more significant increase in ADC compared to sole chemotherapy group. This implies that Sunitinib may have enhanced the chemotherapy effectiveness. The pre-treatment ADC values and the relative changes in tumor volume after chemotherapy were also highly correlated, suggesting that the breast carcinoma with lower pre-treatment ADCs are likely going to respond better to chemotherapy.

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