Early Responses of Breast Cancer Patients to Chemotherapy with and without Anti-angiogenic Pre-treatment Monitored by Diffusion Tensor Imaging
Limiao Jiang 1 , Bo Zhang 2 , Dennis Lai-Hong Cheong 2 , Soo Chin Lee 3 , and Thian C Ng 1,2
Department of Diagnostic Radiology, National
University of Singapore, Singapore, Singapore,
Imaging Research Center, A*STAR & National University of
of Haematology-Oncology, National University Health
DTI can be used to probe tissue microstructure in vivo.
We used DTI to study vasculature alteration including
normalization for enhancing the drug(s) delivery to
breast carcinoma cells in 35 patients pre-treated with
low dose Sunitinib. It showed that patients pre-treated
with anti-angiogenic agent had a more significant
increase in ADC compared to sole chemotherapy group.
This implies that Sunitinib may have enhanced the
chemotherapy effectiveness. The pre-treatment ADC values
and the relative changes in tumor volume after
chemotherapy were also highly correlated, suggesting
that the breast carcinoma with lower pre-treatment ADCs
are likely going to respond better to chemotherapy.
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