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Abstract #0719

Time efficient and robust perfusion measurement using Walsh-reordered time encoded pCASL

Federico von Samson-Himmelstjerna 1 , Jan Sobesky 2 , and Matthias Gnther 1

1 Fraunhofer MEVIS, Bremen, Bremen, Germany, 2 Center for Stroke Research (CSB), Charit University Medicine Berlin, Berlin, Germany

Time encoded (a.k.a Hadamard) pseudo continuous ASL decodes N-1 time steps from N image acquisitions. All N images are necessary for correct decoding. This means, that corrupted images, e.g. by motion, can lead to erroneous decoding and, thus, complete loss of data. To overcome this limitation a Walsh-ordered and extended Hadamard matrix is proposed for encoding. It allows the reconstruction of perfusion data from the second image acquisition on and a time resolution that increases with the number of acquisitions. This renders the technique robust against complete loss of data e.g. by motion of agitated patients in the clinical setup.

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