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Abstract #0727

Flow and permeability estimation from DCE data: 2-compartment exchange and Tofts models comparison

Guy Nadav 1,2 , Gilad Liberman 2,3 , Moran Artzi 2,4 , Nahum Kiryati 1 , and Dafna Ben Bashat 2,4

1 School of Electrical Engineering, Tel Aviv University, Tel Aviv, Israel, 2 Functional Brain Center, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, 3 3Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Israel, 4 Sackler Faculty of Medicine and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel

In order to extract flow from DCE data, a 2-compartment exchange model (2CXM) is needed. In this study we show that flow is misinterpreted as permeability using the standard 1-compartment model (ETM) on simulated data that is based on 2CXM parameters. In real data, obtained from a patient with brain tumor, highly vascularized brain areas (veins and tumor) showed high flow and no permeability using 2CXM, but high permeability using ETM. This study shows that when utilizing ETM, care should be taken when interpreting permeability maps and when temporal resolution allows, the 2CXM should be used.

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