Abstract #0729
The arterial response function: A new concept demonstrated in a simulation study investigating the influence of the injection rate on the quantification of plasma flow
Michael Ingrisch 1 , Steven Sourbron 2 , Felix Schwab 1 , Mike Notohamiprodjo 3 , Maximilian F Reiser 3 , Michael Peller 1 , and Olaf Dietrich 1
1
Josef Lissner Laboratory for Biomedical
Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University
Hospital Munich, Mnchen, Germany,
2
Division
of Medical Physics, University of Leeds, Leeds, United
Kingdom,
3
Institute
for Clinical Radiology, Ludwig-Maximilians-University
Hospital Munich, Mnchen, Germany
The arterial input function (AIF) can be interpreted as
the response of the arterial system to the injection of
contrast agent, characterized by an unknown arterial
response function (ARF). This function can be
determined from a measured AIF by numerical
deconvolution and can be utilized for the generation of
synthetic AIFs for arbitrary injection schemes. In this
work, we use this approach for a simulation study,
investigating the hypothesis that fast injections are
required for the determination of plasma flow in tissues
with short plasma transit times, whereas in tissues with
long transit times slower injections suffice.
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