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Abstract #0729

The arterial response function: A new concept demonstrated in a simulation study investigating the influence of the injection rate on the quantification of plasma flow

Michael Ingrisch 1 , Steven Sourbron 2 , Felix Schwab 1 , Mike Notohamiprodjo 3 , Maximilian F Reiser 3 , Michael Peller 1 , and Olaf Dietrich 1

1 Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Mnchen, Germany, 2 Division of Medical Physics, University of Leeds, Leeds, United Kingdom, 3 Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Mnchen, Germany

The arterial input function (AIF) can be interpreted as the response of the arterial system to the injection of contrast agent, characterized by an unknown arterial response function (ARF). This function can be determined from a measured AIF by numerical deconvolution and can be utilized for the generation of synthetic AIFs for arbitrary injection schemes. In this work, we use this approach for a simulation study, investigating the hypothesis that fast injections are required for the determination of plasma flow in tissues with short plasma transit times, whereas in tissues with long transit times slower injections suffice.

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