Abstract #0731
Fixel-Based Morphometry: Whole-Brain White Matter Morphometry in the Presence of Crossing Fibres
David Raffelt 1 , Robert E Smith 1 , Donald Tournier 1,2 , David Vaughan 1,3 , Graeme Jackson 1,3 , and Alan Connelly 1,2
1
Florey Institute of Neuroscience and Mental
Health, Melbourne, VIC, Australia,
2
Department
of Medicine, University of Melbourne, Melbourne, VIC,
Australia,
3
Department
of Neurology, Austin Health, Melbourne, VIC, Australia
When investigating morphometric white matter differences
between populations, the direction of expansion or
contraction relative to the underlying fibre tract is
important. Expansion or contraction parallel to the
fibre orientation implies a difference in axon length,
while a change to the cross sectional area (CSA) in the
perpendicular plane implies a difference in the number
of axons and is therefore more relevant. We propose a
method that uses Fibre Orientation Distributions to
resolve multiple populations of fibres within each voxel
(fixels). We perform whole-brain statistical
comparisons of the change in fixel CSA across groups in
a method called fixel-based morphometry.
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