Abstract #0756
Dynamic modelling of layer specific cortical temperature for quantitative fMRI
Anna Gaglianese 1,2 , Peter Herman 1 , Daniel Coman 1 , Pietro Pietrini 2,3 , and Fahmeed Hyder 1,4
1
Department of Diagnostic Radiology -
Magnetic Resonance Research Center, School of Medicine,
Yale University, New Haven, CT, United States,
2
Laboratory
of Clinical Biochemistry and Molecular Biology,
Department of Surgical, Medical, Molecular Pathology and
Critical Area, University of Pisa, Pisa, Italy,
3
Clinical
Psychology Branch, Pisa University Hospital, Pisa,
Italy,
4
3Department
of Biomedical Engineering, School of Engineering and
Applied Science, Yale University, New Haven, CT, United
States
Characterizing the relationship between neurovascular
and neurometabolic changes that occurs in the brain is
crucial for fMRI measurements. Here, we developed a
model that relates changes in temperature in space and
time to layer specific variations of CBF, CBV and BOLD
acquired with differente tecniques and CMR
02
measured
by calibrated MRI, under rest and stimulation. We
estimated and measured temperature changes nearly 0.1 C
in the middle/lower layers in agreement with a tighter
coupling between CBF and CMR
02
during
stimulation. Temperature mapping and fMRI measurements
may provide an useful tool to measure metabolic and
hemodynamic variations in the brain.
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