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Abstract #0762

In Vivo Monitoring of Liver Glycogen by Chemical Exchange Saturation Transfer Imaging (GlycoCEST) in Live Mice

Koji Sagiyama 1 , Shanrong Zhang 1 , Ivan Dimitrov 1,2 , A. Dean Sherry 1 , and Masaya Takahashi 1

1 Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, United States, 2 Philips Medical Systems, Cleveland, Ohio, United States

GlycoCEST imaging is one subset of the chemical exchange saturation transfer (CEST) imaging methods which refers specifically to detecting tissue glycogen, which may enable investigation of both normal physiology and various liver diseases. In the present study, we performed phantom and in vivo glycoCEST imaging to detect glycogen and to monitor temporal changes of tissue glycogen concentration in the liver in mice before and after fasting. Our results showed the potential of glycoCEST to study glycogenolysis in vivo.

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