Fat-Constrained Reconstruction of 18F FDG Accumulation in an Integrated PET/MR System using MR Dixon Imaging
Sven Prevrhal 1 , Susanne Heinzer 2 , Bndicte Delattre 2,3 , Steffen Renisch 4 , Christian Wlker 5 , Osman Ratib 3 , and Peter Brnert 1
Philips Research, Hamburg, Germany,
AG Healthcare, Zurich, Switzerland,
Hospital of Geneva, Geneva, Switzerland,
Research, Hamburg, Deutschland, Germany,
of Heidelberg, Germany
The fusion of the information from PET and MRI can
increase the diagnostic value of both modalities.
Compared to MRI, PET has limited spatial resolution,
which could potentially be improved by using the
information MRI can deliver. In this work the hypothesis
was employed that fatty tissue is metabolically not very
active in terms of glucose consumption. Thus, a PET
tracer like 18F-deoxyglucose (FDG) has limited
accumulation in fatty tissue and should have no
significant PET signal in this compartment. Thus, the
fat distribution measured in water/fat-resolved mDixon
MRI can be used as a prior in an appropriately modified
PET image reconstruction. Phantom and in vivo results
show the basic feasibility of this approach.
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