Is the Gaussian Phase Approximation Valid for the Blood Compartment in IVIM Imaging?

The intravoxel incoherent motion signal calculated from normalized phase distributions is compared to the signal obtained using Gaussian phase approximation (GPA). For physiological parameters found in liver and pancreas, the GPA breaks down for b-values > 50 s/mm for flow compensated gradient profiles or when a parabolic distribution of blood flow velocities is assumed. Moreover It is shown that the pseudo-diffusion coefficient D* as defined by Le Bihan is typically underestimated when calculated from a biexponential fit. Since the GPA doesnt hold in general, the use of normalized phase distributions is strongly recommended for quantification of intravoxel incoherent motion parameters.

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