Is the Gaussian Phase Approximation Valid for the Blood Compartment in IVIM Imaging?
Andreas Wetscherek 1 and Frederik Bernd Laun 1,2
Medical Physics in Radiology (E020), DKFZ,
Imaging-Based Disease Characterization (E011), DKFZ,
The intravoxel incoherent motion signal calculated from
normalized phase distributions is compared to the signal
obtained using Gaussian phase approximation (GPA). For
physiological parameters found in liver and pancreas,
the GPA breaks down for b-values > 50 s/mm for flow
compensated gradient profiles or when a parabolic
distribution of blood flow velocities is assumed.
Moreover It is shown that the pseudo-diffusion
coefficient D* as defined by Le Bihan is typically
underestimated when calculated from a biexponential fit.
Since the GPA doesnt hold in general, the use of
normalized phase distributions is strongly recommended
for quantification of intravoxel incoherent motion
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