GABA and glutamate in schizophrenia: a 7T 1H-MRS study
Anouk Marsman 1 , Rene C.W. Mandl 1 , Dennis W.J. Klomp 2 , Marc M. Bohlken 1 , Vincent O. Boer 2 , Anna Andreychenko 3 , Wiepke Cahn 1 , Rene S. Kahn 1 , Peter R. Luijten 2 , and Hilleke E. Hulshoff Pol 1
Psychiatry, University Medical Center
Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Netherlands,
University Medical Center Utrecht, Utrecht, Netherlands
Schizophrenia is characterized by a loss of brain
tissue, which may represent an ongoing
pathophysiological process. The GABAergic and
glutamatergic systems may be involved. Performing 1H-MRS
at an ultra-high magnetic field strength of 7T results
in increased sensitivity and spectral resolution, which
is particularly important when measuring glutamate and
GABA. We conducted a 7T 1H-MRS study to examine
differences in GABA and glutamate levels between
patients with schizophrenia and healthy controls.
Prefrontal GABA/Cr ratios in patients were significantly
lower as compared to controls. Moreover, prefrontal
GABA/Cr ratios in patients were strongly associated with
their level of general cognitive functioning.
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