A blunted response to dextro-amphetamine in recreational dextro-amphetamine users assessed using [ 123 I]IBZM SPECT and pCASL based phMRI.
Anouk Schrantee 1 , Lena Vaclavu 1 , Dennis F R Heijtel 1 , Matthan W A Caan 1 , Jan Booij 1 , Aart J Nederveen 1 , and Liesbeth Reneman 1
Academic Medical Center, Amsterdam,
In this study we compared acute dextro-amphetamine (dAMPH)-induced
changes in cerebral blood flow (CBF) as measured with a
pCASL sequence between regular dAMPH users and healthy
controls. In addition, dopamine release was measured
I]IBZM SPECT. DAMPH administration
decreased gray matter CBF in both groups. However, dAMPH
induced increases in striatal CBF in controls, whereas
this effect was blunted in dAMPH users. Furthermore,
dopamine release was blunted in users compared to
controls as measured with SPECT. These findings suggest
a dysfunctional dopamine system in dAMPH users and also
highlights the potential of phMRI to assess changes in
dopamine neurotransmitter function.
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