Abstract #0842
Hypoxia and HIF silencing dysregulates total choline, CD44 expression, and metastatic burden in MDA-MB-231 human breast cancers
Balaji Krishnamachary 1 , Santosh Kumar Bharti 1 , Marie-France Pennet 1 , Samata M Kakkad 1 , Flonne Wildes 1 , Keve Zoltani 1 , Yelena Mironchik 1 , and Zaver M Bhujwalla 1
1
Radiology, Johns Hopkins University,
Baltimore, MD, United States
Hypoxic tumors frequently exhibit an aggressive
phenotype due to dysregulated gene expression and
metabolic changes. Cancers typically exhibit elevated
phosphocholine mostly due to increased choline kinase
expression and activity. Here we have established a
relationship between hypoxia inducible factor (HIF) and
choline distribution in vivo, and have shown that
silencing both HIF-1α and HIF-2α reduces total choline
and metastatic burden. We have identified a role for
CD44, a breast cancer stem-like cell marker, in lung
colonization
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