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Abstract #0850

Metabolic characterization of triple negative breast cancer

Guro Fannelb Giskedegrd 1,2 , Maria Dung Cao 1,2 , Santosh Lamichhane 3 , Beathe Sitter 4 , Anna Bofin 5 , Steinar Lundgren 2 , Hans Fjsne 2 , and Tone Frost Bathen 1

1 Dept. of Circulation and Medical Imaging, NTNU, Trondheim, Norway, 2 St. Olavs University Hospital, Trondheim, Norway, 3 Department of Food Science, Aarhus University, Denmark, 4 Sr-Trndelag University College, Norway, 5 NTNU, Trondheim, Norway

Triple negative breast cancer (TNBC), characterized by estrogen receptor (ER), progesterone receptor (PgR) and HER2 negativity, represents 15-20% of all breast cancer cases. TNBC is associated with more aggressive and higher grade tumors and poor prognosis. Current treatment options for TNCB are few and the responses are often insufficient. Novel molecular targets for the treatment of TNBC are needed to improve treatment care and survival of this breast cancer subgroup. The purpose of this study was to characterize metabolic differences between TNBC as compared to triple positive breast cancer and to identify potential molecular markers of TNBC tumors for targeted treatment.

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