Abstract #0852
Preoperative imaging in patients undergoing trachelectomy for cervical cancer: validation of endovaginal T2- with diffusion-weighted MRI at 3.0T
Katherine Downey 1 , John H Shepherd 2 , Ayoma D Attygalle 3 , Steve Hazell 3 , Veronica A Morgan 4 , Sharon L Giles 4 , Thomas J Ind 2 , and Nandita M DeSouza 1
1
Clinical Magnetic Resonance Unit, Institute
of Cancer Research, Sutton, Surrey, United Kingdom,
2
Department
of Gynecology, Royal Marsden Hospital, Sutton, Surrey,
United Kingdom,
3
Department
of Histopathology, Royal Marsden Hospital, Sutton,
Surrey, United Kingdom,
4
Clinical
Magnetic Resonance Unit, Royal Marsden Hospital, Sutton,
Surrey, United Kingdom
Combined T2-W and ZOOM-DW endovaginal MRI in women with
cervical cancer treated with fertility-sparing surgery
shows good correlation between MRI and histological
estimates of tumor size (0.8 and 0.86 Observers 1&2,
p<0.0001) and volume (0.79 and 0.52 Observers 1&2,
p<0.01). Sensitivity and specificity for detecting
tumors (median volume 0.31cm3) was 86.7% and 80.0%
respectively. The ratio between MRI and histology
measurements for length of uninvolved endocervical canal
above tumor was 1.7 + 1.1 (Observer 1) 1.7 + 1.3
(Observer 2); MRI underestimated the available length of
normal endocervical canal in 5% (1/19) cases.
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