Improved cortical boundary registration for locally distorted fMRI

We propose a registration method that corrects local distortion in functional scans, using the brain surfaces as constructed by FreeSurfer. An iterative procedure of Boundary Based Registration (Greve & Fischl 2009) is used in a multiscale approach to register parts of the brain, first at the whole-brain level, then at smaller levels. The specificity increases at each stage and accurately and robustly corrects for local mismatches between the structural and the functional volumes. This non-linear registration greatly improves the spatial accuracy, which allows for laminar analysis.

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