Abstract #0871
The viscoelastic response of the human brain to functional activation detected by magnetic resonance elastography
Andreas Fehlner 1 , Sebastian Hirsch 1 , Jing Guo 1 , Jrgen Braun 2 , and Ingolf Sack 1
1
Department of Radiology, Charit -
Universittsmedizin Berlin, Berlin, Germany,
2
Department
of Medical Informatics, Charit - Universittsmedizin
Berlin, Berlin, Germany
This study is on the human brain's mechanical response
to functional activation by fast single shot MR
elastography (MRE). In a total of 57 volunteers we
observed a significant reduction of cerebral
viscoelasticity in the order of 2.5% due to visual
stimulation. The sensitivity of functional MRE was
higher at very low vibration frequencies of 25 and 30 Hz
compared to 40 and 50 Hz indicating the involvement of
poroelastic effects. In contrast to activity patterns
revealed by BOLD fMRI, the viscoelastic response to
brain function appears to be a global phenomenon which
may arise from activity-induced alteration of micro
vascular pressure and effective tissue pressure.
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