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Abstract #0871

The viscoelastic response of the human brain to functional activation detected by magnetic resonance elastography

Andreas Fehlner 1 , Sebastian Hirsch 1 , Jing Guo 1 , Jrgen Braun 2 , and Ingolf Sack 1

1 Department of Radiology, Charit - Universittsmedizin Berlin, Berlin, Germany, 2 Department of Medical Informatics, Charit - Universittsmedizin Berlin, Berlin, Germany

This study is on the human brain's mechanical response to functional activation by fast single shot MR elastography (MRE). In a total of 57 volunteers we observed a significant reduction of cerebral viscoelasticity in the order of 2.5% due to visual stimulation. The sensitivity of functional MRE was higher at very low vibration frequencies of 25 and 30 Hz compared to 40 and 50 Hz indicating the involvement of poroelastic effects. In contrast to activity patterns revealed by BOLD fMRI, the viscoelastic response to brain function appears to be a global phenomenon which may arise from activity-induced alteration of micro vascular pressure and effective tissue pressure.

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