Abstract #0881
Quantitative 3D Myocardial Perfusion Imaging at High Dose with Accurate Arterial Input Function Assessment
Lukas Wissmann 1 , Markus Niemann 1,2 , Robert Manka 1,2 , and Sebastian Kozerke 1,3
1
Institute for Biomedical Engineering,
University and ETH Zurich, Zurich, Switzerland,
2
Department
of Cardiology, University Hospital Zurich, Zurich,
Switzerland,
3
Division
of Imaging Sciences & Biomedical Engineering, King's
College London, London, United Kingdom
First-pass myocardial perfusion imaging requires high
contrast agent dose to achieve sufficient
contrast-to-noise ratio for reliable qualitative
diagnosis. On the other hand, myocardial blood flow
quantification at high dose suffers from signal
saturation. In conventional approaches this results in
underestimation of the peak arterial input function,
leading to overestimation of myocardial blood flow. The
study at hand presents an interleaved 2D AIF navigator
for whole-heart 3D perfusion imaging. It is demonstrated
that accurate quantification of blood flow is achieved
while maintaining excellent contrast-to-noise ratios for
simultaneous qualitative assessment with high-dose
contrast injections.
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