Abstract #0900
Altered magnetic susceptibility in white matter after mild traumatic brain injury
Wei Li 1,2 , Justin Long 1 , Lora Talley Watts 1 , Qiang Shen 1 , and Timothy Q Duong 1,2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Ophthalmology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX, United States
The white matter damage and its related alterations in
brain structural connectivity can be an important factor
in determining the neurobehavioral outcomes after
traumatic brain injury. This study explored the use of
magnetic susceptibility, a novel contrast determined
from gradient echo signal phase, for the
characterization of white matter changes following mild
TBI using a rat model. We found that magnetic
susceptibility imaging offers improved sensitivity to
white matter changes compared to DTI FA. This study
showed the potential of magnetic susceptibility for
sensitive detection of white matter damages in vivo.
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