Preferably large fiber damage in the corpus callosum of progressive MS compared with relapsing MS and controls

We recruited 19 patients with advance SPMS and mild RRMS and 19 controls to determine whether tissue damage differs across different regions of the corpus callosum (CC) and between cohorts. Using whole-brain sagittal DTI, we developed a simple template to partition the CC into 6 segments. We found tissue organization different between CC segments and tissue damage the greatest in the body and splenium, which are comprised of large-caliber axons, of SPMS. There was only minimal tissue injury in RRMS but in similar locations. Our results suggest the vulnerability of large-caliber axons likely causing advanced disability in SPMS.

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