Abstract #0904
Diffusion abnormalities in the spinal cord grey matter relates to disability in relapse-onset multiple sclerosis
Hugh Kearney 1 , Torben Schneider 1 , Marios C. Yiannakas 1 , Claudia A.M. Wheeler-Kingshott 1 , Olga Ciccarelli 1,2 , and David H. Miller 1,2
1
NMR Research Unit, UCL Institute of
Neurology, London, United Kingdom,
2
NIHR
University College London Hospitals Biomedical Research
Centre, London, United Kingdom
We have quantified spinal cord abnormalities in people
with relapse-onset multiple sclerosis (MS) using
diffusion tensor imaging (DTI) in specific white matter
and grey matter tracts. Abnormal DTI metrics were
evident in the spinal cord of people with clinically
isolated syndrome prior to the accumulation of
significant levels of physical disability. In both
relapsing remitting and secondary progressive MS, DTI
values also differed significantly from controls. In the
MS cohort (i.e. excluding CIS) there were a number of
significant correlations with physical disability in
both white matter tracts and the central spinal cord
grey matter.
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