Abstract #0910
Perivascular spaces in MS patients at 7 Tesla MRI: a marker of neurodegeneration?
Iris D Kilsdonk 1 , Martijn D Steenwijk 1 , Petra Pouwels 2 , Jaco JM Zwanenburg 3 , Jeroen JG Geurts 4 , Frederik Barkhof 1 , and Mike P Wattjes 1
1
Radiology and Nuclear Medicine, VU
University medical center, Amsterdam, Noord Holland,
Netherlands,
2
Physics
and Medical Technology, VU University medical center,
Amsterdam, Noord Holland, Netherlands,
3
Radiology,
University Medical Center Utrecht, Utrecht, Utrecht,
Netherlands,
4
Anatomy and Neurosciences, VU
University medical center, Amsterdam, Noord Holland,
Netherlands
Enlarged perivascular spaces - Virchow Robin Spaces (VRS)
- in 34 multiple sclerosis (MS) patients and 11 healthy
controls were analyzed with high resolution structural
MRI at 7T. VRS were measured and related to inflammatory
(MS lesion load) and neurodegenerative (brain atrophy)
variables. Compared to controls, MS patients showed an
increased number of VRS, which was associated with
supratentorial brain atrophy, age and disease duration,
but not with lesion load. This suggests that VRS might
rather serve as a neurodegenerative than an inflammatory
radiological marker in MS.
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