Abstract #0952
FUNCTIONAL MAGNETIC RESONANCE IMAGING REVEALS BRAIN CORTEX REMODELING IN A RAT MODEL OF CHRONIC MULTIPLE SCLEROSIS
Stefano Tambalo 1 , Silvia Fiorini 1 , Roberta Rigolio 2 , Pietro Bontempi 1 , Andrea Sbarbati 3 , Guido Cavaletti 2 , Paola Marmiroli 2 , Stefano Pluchino 4 , and Pasquina Marzola 5
1
Dept. of Neuological and Movement Science,
Universit di Verona, Verona, Verona, Italy,
2
Dept.
of Surgery and Translational Medicine, Universit
Milano-Bicocca, Milano, Italy,
3
Dept.
of Neuological and Movement Science, INSTM Firenze,
Verona, Italy,
4
Dept
of Clinical Neurosciences, John Van Geest Centre for
Brain Repair, Stem Cell Institute and NIHR, University
of Cambridge, Cambridge, United Kingdom,
5
Dept.
of Informatics, University of Verona, Verona, Italy
Experimental Autoimmune Encephalomyelitis (EAE) is a
good model of Multiple Sclerosis in rodents. We have
applied fMRI to invesigate the alteration in functional
response in rats induced with EAE. Cortical activation
is altered in EAE rat brain, compared to controls. fMRI
showed an increase in the activated volume involving
also the cortex ipsilateral and some extra-cortical
areas at the observed time points. These results
demonstrate brain cortex remodeling in EAE, a remakable
feature of MS. The present model seems to be a relevant
tool in preclinical MS studies.
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