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Abstract #0957

Multimodal imaging analysis in the assessment of gray and white matter damage in multiple sclerosis

Niels Bergsland 1,2 , Marcella Lagan 1 , Eleonora Tavazzi 1 , Matteo Caffini 2 , Paola Tortorella 1 , Marco Rovaris 1 , and Giuseppe Baselli 2

1 Istituto IRCCS Santa Maria Nascente, Fondazione Don Gnocchi, Milan, Italy, 2 Dipartimento di Elettronica, Informatica e Bioingegneria, Politecnico di Milano, Milan, Italy

The study of the relationship between grey matter (GM) and white matter damage in multiple sclerosis (MS) is relevant. This was a cross-sectional MRI study of 30 MS patients. Probabilistic tractography data and lesion load of the cortico-spinal tract (CST) were obtained. Measures of motor cortex (MC) thickness and area were obtained with Freesurfer. MC thickness correlated with CST mean diffusivity and lesion volume, and EDSS. MC surface area correlated with EDSS. Our findings further characterize the GM damage and confirm its impact of on disability. CST damage correlated with cortical thickness supporting the link between GM and WM damage.

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