Abstract #0965
EVALUATION OF DIFFUSION-WEIGHTED IMAGING AS A PROGNOSTIC BIOMARKER IN CASTRATION RESISTANT PROSTATE CANCER WITH BONE METASTASES
Raquel Perez-Lopez 1,2 , Matthew D. Blacklegde 1 , David Lorente 1,2 , Ulrike Naumann 1 , Joaquin Mateo 1,2 , Thian Yiliang 2 , Zaki Ahmad 2 , David J. Collins 1 , Martin O. Leach 1 , Gerhardt Attard 1,2 , Johann S. de Bono 1,2 , Dow-Mu Koh 1,2 , and Nina Tunariu 1,2
1
The Institute of Cancer Research, Sutton,
Surrey, United Kingdom,
2
The
Royal Marsden NHS Trust, Sutton, Surrey, United Kingdom
We conducted a study in patients with metastatic
castration-resistant prostate cancer (mCRPC) and bone
metastases, to evaluate if parameters derived from DWI
(volume of bone disease and ADC values distribution in
the bone metastases) confer prognostic information for
overall survival. Whole body DW-MRI from 33 patients
with mCRPC and bone involvement were analyzed and data
were correlated with clinical variables. Our results
show that the volume of bone disease assessed by DWI,
and more so the volume of disease with ADC values
between 750-1450 μm2/s, are a strong prognostic
biomarker for overall survival in mCRPC and correlate
with clinically relevant variables.
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