Abstract #0967
3D High Resolution Diffusion-Weighted MRI at 3T: Preliminary Application in Patients undergoing Active Surveillance Protocol for Low-Risk Prostate Cancer
Christopher Nguyen 1,2 , Zhaoyang Fan 1 , Ali Afshar 3 , Yibin Xie 1,2 , Rola Saouaf 4 , Hyung Kim 3 , and Debiao Li 1,2
1
Biomedical Imaging Research Institute,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States,
2
Bioengineering,
University of California Los Angeles, Los Angeles, CA,
United States,
3
Surgery,
Urology Division, Cedars-Sinai Medical Center, Los
Angeles, CA, United States,
4
Radiology,
Cedars-Sinai Medical Center, Los Angeles, CA, United
States
We developed a novel 3D diffusion-prepared multi-shot
balanced steady-state free precession technique capable
of improved spatial resolution, image quality, and
lesion contrast-to-noise ratio compared with single-shot
diffusion-weighted echo planar imaging (SS DW EPI),
while maintaining quantitative estimation of trace
apparent diffusion coefficient. Because of these
technical advances, the proposed technique yielded
significantly better sensitivity, PPV, NPV, and AUC in
detecting biopsy-confirmed lesions compared with SS DW
EPI in a small group of prostate cancer patients
undergoing active surveillance (AS-PC). By improving
lesion detection, the proposed technique may allow DW
MRI to potentially monitor low-risk prostate cancer
lesions in AS-PC.
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