Abstract #0998
Optimization of 3D turbo GluCEST MRI of healthy brain at 7T
Kejia Cai 1,2 , Hari Hariharan 1 , Anup Singh 1 , Mohammad Haris 1,3 , Kevin D'Aquilla 1 , Ravi Prakash Reddy Nanga 1 , Feliks Kogan 1 , and Ravinder Reddy 1
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
CMRR
3T Research Program, Radiology, University of Illinois
at Chicago, Illinois, IL, United States,
3
Sidra
Medical and Research Center, Doha, Qatar, United States
Glutamate (Glu) is the primary neurotransmitter
responsible for excitatory synaptic transmission in the
central nervous system. Excessive Glu in the synaptic
space can trigger a toxic cascade leading to neuronal
death, which has been implicated in a wide range of
neurological and psychiatric disorders. GluCEST, an
imaging technique that utilizes the chemical exchange
saturation effect of Glu has been exploited for mapping
single-slice Glu in brain and spinal cord at the
ultra-high field 7T. However, 3D GluCEST mapping may be
necessary to localize Glu abnormalities in a large brain
volume. The purpose of this study is to extend the 2D
GluCEST for 3D imaging. A turbo acquisition method has
been investigated and optimized for scan time
efficiency.
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