Simultaneous quantification of oxygen extraction fraction, vessel radius and cerebral blood volume by respiratory-calibrated MRI
Michael Germuska 1 and Daniel Bulte 2
Cardiff University Brain Research Imaging
Centre, University of Cardiff, Cardiff, United Kingdom,
Dept. of Clinical Neurosciences, Oxford University,
Oxford, Oxon, United Kingdom
Recently, respiratory-calibrated MRI methods capable of
providing a quantitative assessment of cerebral
physiology have been developed. In this study we combine
hyperoxic and hypercapnic calibration of the BOLD signal
with a simultaneous BOLD measurement of vessel size. The
combination of these methods allows for the elimination
of significant physiological assumptions from each of
the combined techniques. Modelling results show that the
new method produces accurate estimates over a wider
range of physiological states than each of the combined
methods, broadening the scope of such measurements.
Results from pilot data in healthy volunteers agrees
well with expected mean values.
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