Simultaneous quantification of oxygen extraction fraction, vessel radius and cerebral blood volume by respiratory-calibrated MRI

Recently, respiratory-calibrated MRI methods capable of providing a quantitative assessment of cerebral physiology have been developed. In this study we combine hyperoxic and hypercapnic calibration of the BOLD signal with a simultaneous BOLD measurement of vessel size. The combination of these methods allows for the elimination of significant physiological assumptions from each of the combined techniques. Modelling results show that the new method produces accurate estimates over a wider range of physiological states than each of the combined methods, broadening the scope of such measurements. Results from pilot data in healthy volunteers agrees well with expected mean values.

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