DWI of Breast at 3T: Effects of Fibroglandular Tissue Composition and Background Parenchymal Enhancement in Patients with Malignant and Benign Lesions

The amount of fibroglandular tissue (FGT) density and the level of background parenchymal enhancement (BPE) are MRI features of normal breast. Studies showed increased BPE to be strongly predictive of breast cancer odds as with increased FGT. We propose to evaluate the effect of FGT density and BPE on ADC values in patients with malignant and benign findings at 3.0T. FGT-ADC values were significantly higher in patients with malignant lesions with higher density compared to lower density (p=0.0073). In patients with benign lesions, difference is smaller between both groups (p=0.015). No significant difference was observed in FGT-ADC values with BPE.

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