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Abstract #1046

A novel and affordable DCE-MRI phantom: Prospective assessment of DCE-MRI breast protocols

Araminta E. W. Ledger 1 , Marco Borri 1 , Hector Sanchez Casas 1 , Craig Cummings 1 , Maria A. Schmidt 1 , and Martin O. Leach 1

1 CR-UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, Surrey, United Kingdom

DCE-MRI is an established component of breast screening protocols, and uses the empirical classification of contrast agent (CA) enhancement curves to aid diagnosis. However, CA enhancement curves resulting from varying parameter selections are difficult to assess prospectively. This abstract uses a novel and affordable DCE-MRI phantom to assess the effect of common sequence alterations (CA injection timing and k-space sampling scheme) on the CA enhancement curves obtained from two clinical DCE-MRI sequences. Both CA injection timing and k-space sampling pattern resulted in measurable curve differences - sequence comparison with this phantom can therefore help to establish robust DCE-MRI breast protocols.

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