Abstract #1053
Factors Affecting ADC Measures in Breast Cancer Patients
Shelley Waugh 1 , Lukasz Priba 1 , and Sarah Vinnicombe 2
1
Medical Physics, Ninewells Hospital, Dundee,
Angus, United Kingdom,
2
Division
of Cancer Research, University of Dundee, Dundee, United
Kingdom
The aim of this study was to identify the contribution
of various factors that may have an impact on accuracy
of measurements of apparent diffusion coefficients (ADC)
in breast MRI. We have considered the effect of
long-term scanner stability, positional dependence
within the coil, scan-scan repeatability and the effect
of single and multiple observers on final measurements
of whole tumour and lowest ADC values within tumours. We
conclude that scan-scan repeatability and scanner
stability have minimal effect on measured ADC values and
the biggest influence on measured ADC values is
inter-observer repeatability.
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