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Abstract #1055

High Spatial Resolution DTI Sequence for Characterizing Breast Tumor Early Treatment Response: Comparison to Standard DTI Sequence

Lisa Wilmes 1 , Wei Ching Lo 2 , David C Newitt 2 , Suchandrima Banerjee 3 , Evelyn Proctor 2 , Emine Saritas 4 , Ajit Shankaranarayanan 3 , and Nola M Hylton 2

1 University of California San Francisco, San Francisco, CA, United States, 2 University of California San Francisco, CA, United States, 3 Applied Science Laboratory GE Healthcare, CA, United States, 4 University of California Berkeley, CA, United States

A high-resolution reduced field of view diffusion tensor weighted imaging sequence (HR-DTI), voxel size 4.8 mm3, was optimized for breast imaging and compared to a standard FOV DTI sequence (STD-DTI), voxel size 29.3 mm3, for evaluating tumor response to treatment in seven breast cancer patients undergoing neoadjuvant chemotherapy. Significant differences were found between the tumor fractional anisotropy (FA) measured by HR-DTI and the STD-DTI prior to and early in treatment. Of the DTI parameters evaluated, HR-DTI FA correlated most strongly with tumor volume change post treatment. This preliminary study suggest that HR-DTI may be sensitive to treatment-induced changes in tumors.

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