Abstract #1058
Using MRI to characterize lymphatic structure and function without exogenous contrast agents
Paula Donahue 1 , Swati Rane 2 , Seth Smith 2 , and Manus Donahue 2
1
Physical Medicine and Rehabilitation, Dayani
Center for Health and Wellness, Vanderbilt University
School of Medicine, Nashville, TN, United States,
2
Radiology,
Vanderbilt University School of Medicine, TN, United
States
The overall objective of this work is to translate
noninvasive imaging techniques for measuring brain
structure and function to the lymphatic system to
characterize axillary lymphatic vessel structure and
interstitial protein accumulation in patients with
breast cancer-related lymphedema (BCRL). To achieve
this, a multi-faceted, noninvasive 3T MRI protocol for
characterizing lymph node volume (DWIBS MRI), lymph
vessel diameter (3D TSE), lymph flow velocity (spin
labeling MRI), and interstitial protein accumulation
(APT CEST MRI) are optimized and applied in healthy
volunteers (n=10) and patients with BCRL (n=4).
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