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Abstract #1068

Correlating multi-parametric MRI with Gleason score in human prostate cancer

Heling Zhou 1 , Rami R Hallac 2 , Qing Yuan 1 , Yao Ding 3 , Franto Francis 4 , Robert D Sims 1 , Ganesh Raj 5 , and Ralph P Mason 1

1 Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2 Analytical Imaging and Modeling Center, Children's Medical Center, Dallas, TX, United States, 3 Imaging Physics, University of Texas MD Anderson Cancer Center, Houston, TX, United States, 4 Pathology, University of Texas Southwestern Medical Center, Dallas, TX, United States, 5 Urology, University of Texas Southwestern Medical Center, Dallas, TX, United States

Prostate cancer remains the most common malignant tumor in men. Hypoxia is an important prognostic biomarker. In this study, 10 patients with biopsy confirmed prostate cancer underwent MRI studies including oxygen enhanced (BOLD and TOLD), DCE, and diffusion weighted MRI. The multi-parametric maps were intercorrelated and compared with Gleason score. ADC and R 2 * were found to be significantly different from normal prostate and showed general trends of decrease with higher Gleason score. A multi-parametric approach is feasible and provides insights into tumor pathophysiology.

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