Abstract #1068
Correlating multi-parametric MRI with Gleason score in human prostate cancer
Heling Zhou 1 , Rami R Hallac 2 , Qing Yuan 1 , Yao Ding 3 , Franto Francis 4 , Robert D Sims 1 , Ganesh Raj 5 , and Ralph P Mason 1
1
Radiology, University of Texas Southwestern
Medical Center, Dallas, TX, United States,
2
Analytical
Imaging and Modeling Center, Children's Medical Center,
Dallas, TX, United States,
3
Imaging
Physics, University of Texas MD Anderson Cancer Center,
Houston, TX, United States,
4
Pathology,
University of Texas Southwestern Medical Center, Dallas,
TX, United States,
5
Urology,
University of Texas Southwestern Medical Center, Dallas,
TX, United States
Prostate cancer remains the most common malignant tumor
in men. Hypoxia is an important prognostic biomarker. In
this study, 10 patients with biopsy confirmed prostate
cancer underwent MRI studies including oxygen enhanced
(BOLD and TOLD), DCE, and diffusion weighted MRI. The
multi-parametric maps were intercorrelated and compared
with Gleason score. ADC and R
2
* were found to
be significantly different from normal prostate and
showed general trends of decrease with higher Gleason
score. A multi-parametric approach is feasible and
provides insights into tumor pathophysiology.
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