ASSESSING THE EFFECTS OF DECREASING TEMPORAL RESOLUTION ON PHARMACOKINETIC ANALYSIS USING A LOCAL VASCULAR INPUT FINCTION
Hatef Mehrabian 1 , Masoom A. Haider 2 , and Anne L. Martel 1
Medical Biophysics, University of Toronto,
Toronto, Ontario, Canada,
Imaging, Sunnybrook Health Sciences Centre, Toronto,
Pharmacokinetic (PK) analysis of tumor DCE-MRI provides
information about its vasculature. Such analysis
requires an AIF, which has a narrow temporal profile,
and its measurement requires data with high temporal
resolution (resulting in low spatial resolution images).
This paper investigates possibility of using a local
vascular input function (VIF) that has a wider temporal
profile and can be measured in low temporal resolution
datasets, in PK analysis and shows VIF-based PK
parameters are less sensitive to low temporal resolution
compared to AIF-based parameters. Lowering temporal
resolution enables imaging with high spatial resolution
which improves both VIF calculation and PK analysis.
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