Abstract #1112
T 1ρ Mapping for the Evaluation of High Intensity Focused Ultrasound Tumor Treatment
Stefanie JCG Hectors 1,2 , Rik PM Moonen 1,2 , Gustav J Strijkers 1,2 , and Klaas Nicolay 1,2
1
Biomedical NMR, Department of Biomedical
Engineering, Eindhoven University of Technology,
Eindhoven, Netherlands,
2
Center
for Imaging Research and Education, Eindhoven,
Netherlands
This study was aimed to assess the effects of HIFU
treatment on tumor T
1ρ
. T
1ρ
measurements
at various spin-lock amplitudes (0-2000 Hz) were
performed before, directly after and 3 days after HIFU
treatment of murine tumors. The tumor T
1ρ
at
spin-lock amplitudes higher than or equal to 100 Hz
significantly decreased at 3 days after HIFU compared to
pre-treatment. The T
1ρ
decline
after HIFU became significantly larger with increasing
spin-lock amplitudes, indicative of increased contrast
between HIFU-treated and non-treated tissue at higher
spin-lock amplitudes. Altogether, the data suggest that
T
1ρ
is
a suitable biomarker for the evaluation of HIFU
treatment.
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