Abstract #1116

Changes in tumor perfusion and oxygenation following CA4P administration

Florence Colliez ¹ , Anne-Catherine Fruytier ¹ , Marie-Aline Neveu ¹ , Julie Magat ¹ , Bernard Gallez ¹ , and Bndicte F Jordan ¹

¹ Louvain Drug Research Institute, Biomedical Magnetic Resonance Research Group, University of Louvain, Brussels, Belgium

Vascular discrupting agents (VDAs) induce tumor hypoxia within 3 hours in preclinical models. Combretastatin A4 phosphate (CA4P) is the lead compound of this agents class. The present work correlates a follow-up on two tumor models of both tumor oxygenation and tumor hemodynamics after CA4P administration. Mapping of tumor oxygenation was assessed with MOBILE (Mapping of Oxygen By Imaging Lipids relaxation Enhancement) a non-invasive MRI method based on the changes in the relaxation properties of the tissue lipids protons whereas tumor hemodynamics (Ktrans and vp) variations were evaluated by DCE-MRI on same tumor models.

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