Abstract #1123
A role for DCE MRI in predicting tumor radiation response
Rami Hallac 1,2 , Heling Zhou 1 , Rajesh Pidikiti 3,4 , Kwang Song 3,5 , Strahinja Stojadinovic 3 , Dawen Zhao 1 , Vikram Kodibagkar 1,6 , Peter Peschke 7 , Timothy Solberg 3,8 , and Ralph Peter Mason 1
1
Radiology, UT Southwestern, Dallas, TX,
United States,
2
Children's
Medical Center, Dallas, TX, United States,
3
Radiation
Oncology, UT Southwestern, Dallas, TX, United States,
4
MD
Anderson, TX, United States,
5
Henry
Ford Hospital, MI, United States,
6
Biological
and Health Systems Engineering, Arizona State
University, Tempe, AZ, United States,
7
German
Cancer Center, Heidelberg, D-69120, Germany,
8
Univ
Pennsylvania, PA, United States
DCE MRI has been extensively studied and suggested to be
a useful method for evaluating tumor hypoxia. Here, we
evaluated correlations between quantitative DCE MRI and
radiation outcome of the well characterized syngeneic
Dunning prostate rat tumor R3327-AT1. Following DCE MRI,
8 tumors were irradiated with a single dose of 30 Gy,
while rats breathed air or oxygen, whereas two served as
non-irradiated controls. Irradiation caused significant
tumor growth delay. Strong correlation was observed
between tumor growth delay and ve, but there no obvious
correlation with Ktrans. High temporal resolution DCE
MRI could provide predictive insight into response to
radiation.
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