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Abstract #1123

A role for DCE MRI in predicting tumor radiation response

Rami Hallac 1,2 , Heling Zhou 1 , Rajesh Pidikiti 3,4 , Kwang Song 3,5 , Strahinja Stojadinovic 3 , Dawen Zhao 1 , Vikram Kodibagkar 1,6 , Peter Peschke 7 , Timothy Solberg 3,8 , and Ralph Peter Mason 1

1 Radiology, UT Southwestern, Dallas, TX, United States, 2 Children's Medical Center, Dallas, TX, United States, 3 Radiation Oncology, UT Southwestern, Dallas, TX, United States, 4 MD Anderson, TX, United States, 5 Henry Ford Hospital, MI, United States, 6 Biological and Health Systems Engineering, Arizona State University, Tempe, AZ, United States, 7 German Cancer Center, Heidelberg, D-69120, Germany, 8 Univ Pennsylvania, PA, United States

DCE MRI has been extensively studied and suggested to be a useful method for evaluating tumor hypoxia. Here, we evaluated correlations between quantitative DCE MRI and radiation outcome of the well characterized syngeneic Dunning prostate rat tumor R3327-AT1. Following DCE MRI, 8 tumors were irradiated with a single dose of 30 Gy, while rats breathed air or oxygen, whereas two served as non-irradiated controls. Irradiation caused significant tumor growth delay. Strong correlation was observed between tumor growth delay and ve, but there no obvious correlation with Ktrans. High temporal resolution DCE MRI could provide predictive insight into response to radiation.

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