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Abstract #1131

pH-sensitive nanoparticle for delivery of lonidamine to triple-negative breast cancer: A preliminary 31P MRS study

Kavindra Nath 1 , Hoon Choi 1 , David S Nelson 1 , Daniel F Heitjan 1 , Dennis B Leeper 2 , Jerry D Glickson 1 , I-Wei Chen 1 , and Rong Zhou 1

1 University of Pennsylvania, Philadelphia, Pennsylvania, United States, 2 Thomas Jefferson University, Philadelphia, Pennsylvania, United States

To exploit the slightly acidic extracellular pH environment of cancer in comparison with normal tissue, we have made ultra pH-responsive peptide nanoparticles to encapsulate lonidamine (LND), an antineoplastic agent, for intravenous administration. Once at tumor site (pHe = 6.9), the nanoparticles melt, releasing LND molecules that diffuse to surrounding cancer cells. In normal tissues (pHe ≥ 7.2), however, LND will not be released as the nanoparticles remain stable. Our results show that pH-responsive nanoparticles efficiently solubilize LND for i.v. injections and substantially increase the tumor bioavailability of LND.

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