Abstract #1131
pH-sensitive nanoparticle for delivery of lonidamine to triple-negative breast cancer: A preliminary 31P MRS study
Kavindra Nath 1 , Hoon Choi 1 , David S Nelson 1 , Daniel F Heitjan 1 , Dennis B Leeper 2 , Jerry D Glickson 1 , I-Wei Chen 1 , and Rong Zhou 1
1
University of Pennsylvania, Philadelphia,
Pennsylvania, United States,
2
Thomas
Jefferson University, Philadelphia, Pennsylvania, United
States
To exploit the slightly acidic extracellular pH
environment of cancer in comparison with normal tissue,
we have made ultra pH-responsive peptide nanoparticles
to encapsulate lonidamine (LND), an antineoplastic
agent, for intravenous administration. Once at tumor
site (pHe = 6.9), the nanoparticles melt, releasing LND
molecules that diffuse to surrounding cancer cells. In
normal tissues (pHe ≥ 7.2), however, LND will not be
released as the nanoparticles remain stable. Our results
show that pH-responsive nanoparticles efficiently
solubilize LND for i.v. injections and substantially
increase the tumor bioavailability of LND.
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