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Abstract #1138

Dynamic MRS of hyperpolarized 1- 13 C pyruvate in brain tumor afflicted mice treated with temozolomide

Teresa Delgado-Goi 1,2 , Eva Monteagudo 3 , Miquel E. Cabaas 3 , Carles Ars 1,2 , and Silvia Lope-Piedrafita 3

1 Department de Bioqumica i Biologia Molecular, Unitat de Bioqumica de Biocincies, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Barcelona, Spain, 2 Centro de Investigacin Biomdica en Red en Bioingeniera, Biomateriales y Nanomedicina (CIBER-BBN), Cerdanyola del Valls, Barcelona, Spain, 3 Servei de RMN, Universitat Autnoma de Barcelona, Cerdanyola del Valls, Barcelona, Spain

In this study we aimed to evaluate the detection of response to temozolomide therapy in a well characterized mouse brain glioma model by hyperpolarized [1-13C] pyruvate. Quantification of time course 13C spectra showed significant differences between wildtype and untreated-glioblastoma-bearing mice in the lactate signals from 12s to 50s post-injection. However no differences were observed in lactate between untreated and treated glioblastoma-bearing mice. Nevertheless, individual Lac/Pyr ratios of treated mice seemed to have two separate patterns, one with increased ratios and the other with smaller values, which could indicate different behavior with respect to therapy response variability in the evaluated mice.

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